The most famous example of terrible movie chemistry came in the 2003 film 'Gigli,' starring Ben Affleck and then-girlfriend Jennifer Lopez. Despite their romantic connection off screen, they weren't very convincing as a couple in this film.
Their chemistry was so notoriously bad that 'Gigli' quickly became known as one of the worst movies ever made. Ouch.
Click through for some more of the worst on-screen chemistry in movie history!