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How can amatoxin lead to death?

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Alpha amatoxin inactivates RNA polymerase II and inhibits protein synthesis, which ultimately leads to cell death. Amanita toxins are found in several Amanita species, even experienced mushroom pickers may mistake death cap which is generally considered the most toxic of the world's cyclopeptide-containing mushrooms, for one of its benign cousins.

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How can amatoxin lead to death?

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