Barrett esophagus (British English: Barrett's oesophagus), sometimes called Barrett syndrome or columnar epithelium lined lower oesophagus (CELLO), refers to an abnormal change (metaplasia) in the cells of the inferior portion of the esophagus. A positive diagnosis generally requires observing specific macroscopic and microscopic changes. The normal squamous epithelium lining of the esophagus is replaced by metaplastic columnar and goblet cells. Columnar epithelium refers to a cell type that is typically found in more distal parts of the gastrointestinal system. Only the presence of goblet cells equates a diagnosis of Barrett esophagus. The medical significance of Barrett esophagus is its strong association with esophageal adenocarcinoma, a particularly lethal cancer. The main cause of...'
Contributions by Kallimachus, Phidbruy, and Arcadian.