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Chromosomes


Chromosomes

Chromosomes are long pieces of DNA that are found in the center (nucleus) of plant, animal and human cells. Each chromosome is made of protein and a single molecule of deoxyribonucleic acid (DNA). DNA is the material that holds genes and it is considered to be the building block of the human body.

About Chromosomes

Chromosomes naturally come in pairs. Each cell in the human body has 23 pairs of chromosomes for a total of 46 chromosomes. Half of those come from the mother and the other half come from the father.

Two of the chromosomes (the X and the Y chromosome) determine if you are born a boy or a girl. They are called the sex chromosomes. Females have 2 X chromosomes while males are 1 X chromosome and 1 Y chromosome.

The mother always contributes an X chromosome to the child. But, the father may contribute an X or a Y chromosome. So, it is the father that determines the gender of the child.

The unique structure of chromosomes keeps DNA tightly wrapped around spool like proteins, called histones. Without this packaging, DNA molecules would be too long to fit inside of the cells. If all of the DNA molecules in a single human cell were unwound from their histones and placed end to end, they would stretch 6 feet. For an organism to grow and function properly, its cells must constantly divide to produce new cells to replace old, worn out cells.

During cell division, it is essential that the DNA remains intact and evenly distributed among the cells. Chromosomes are a key part of the process that ensures DNA is accurately copied and distributed in the vast majority of cell divisions. However, mistakes do occur on rare occasions.

Changes in the number or of the structure of chromosomes in new cells may lead to serious problems. For example, in humans, one type of leukemia and some other cancers are caused by defective chromosomes made up of joined pieces of broken chromosomes.

It is also crucial that reproductive cells, such as eggs and sperm, contain the right number of chromosomes and that those chromosomes have the correct structure.

If they do not, the resulting offspring may fail to develop properly. For example, people with Down syndrome have three copies of chromosome 21, instead of the two copies found in other people.

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