Bush graduated from Dartmouth College in 1818 and went on to study at the Princeton Theological Seminary. Bush was ordained at the Salem Presbytery, Indiana in 1825 and was appointed pastor of a church in Indianapolis. There his 'liberal' or 'progressive' religious views into conflict with those of his more conservative parishioners, leading to
the termination of his services for the church.From 1831 to 1847, Bush was Professor of Hebrew and Oriental Literature at what is now New York University. His first published work, Life of Muhammad, was the first American biography of the founder of Islam. He also began works including: A Grammar of the Hebrew Language (1835), an extensive series of commentaries on books of the Old Testament, and the highly controversial Anastasis: or, the doctrine of the resurrection of the Body, rationally and scripturally considered (1844). He argued for restoring Jews to Palestine. After his death, Bush was remembered for his dedication to the search for knowledge and his large collection of books (Widmer 2007). Mr. Bush was also a committed advocate for the abolishment of slavery. His 1847 "The Valley of Vision," which became an antebellum best