Omeprazole (INN) (/omprzol/) (Prilosec and generics) is a proton pump inhibitor used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD), laryngopharyngeal reflux (LPR) and ZollingerEllison syndrome. Omeprazole is one of the most widely prescribed drugs internationally and is available over the counter in some countries. Used to treat GERD (gastroesophageal reflux disease), gastric and duodenum ulceration and gastritis. Omeprazole is combined with the antibiotics clarithromycin and amoxicillin (or metronidazole in penicillin-hypersensitive patients) in the 714 day eradication triple therapy for Helicobacter pylori. Infection by H. pylori is the causative factor in the majority of peptic ulcers. Omeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell.
Contributions by Techelf, Fvasconcellos, and 126.96.36.199.