Santhanam is a Tamil film actor, who plays comedy roles in Tamil films. His fame started off in the Lollu Sabha. He made his feature film debut in Manmadhan in 2004 and later appeared in several successful films.Though Manmadhan is considered as his first feature film, he has acted in two films before the Manmadhan. Santhanam was also there in STR's debut film as a leading actor , namely Kadhal Azhivathillai. Theoretically Kadhal Azhivathillai should be considered as first film of Santhanam. He is best known for his roles in Siruthai (2011) and director M. Rajesh's comic trilogy, comprising Siva Manasula Sakthi (2009), Boss Engira Bhaskaran (2010) and Oru Kal Oru Kannadi (2012), the former two earning him the Vijay Award for Best Comedian for their respective years.